Oxidative Cleavage of Enamides with Hypervalent Iodine(III)/TMSN₃ under an Air Atmosphere

Abstract

An oxidative cleavage of C–C double bonds of enamides promoted by hypervalent iodine(III)/TMSN₃ under an air atmosphere is developed. This reaction provides a new approach to construct various cyanobenzamides, which offers further synthetic potential for the preparation of industrial and pharmaceutical nitrogen- and oxygen-containing molecules, and exhibits good functional group tolerance, broad substrate scope and mild conditions.

Key words

oxidative cleavage - enamides - hypervalent iodine(III) - TMSN₃ - air atmosphere

• References

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