Synlett 2017; 28(07): 825-830
DOI: 10.1055/s-0036-1588941
letter
© Georg Thieme Verlag Stuttgart · New York

Ph3P/I2-Mediated Synthesis of 3-Aryl-Substituted and 3,4-Disubstituted Coumarins

Wong Phakhodee*
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand   Email: wongp2577@gmail.com
,
Chuthamat Duangkamol
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand   Email: wongp2577@gmail.com
,
Dolnapa Yamano
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand   Email: wongp2577@gmail.com
,
Mookda Pattarawarapan
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand   Email: wongp2577@gmail.com
› Author Affiliations
Further Information

Publication History

Received: 15 December 2016

Accepted after revision: 30 December 2016

Publication Date:
02 February 2017 (online)


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Abstract

Ph3P/I2–Et3N-mediated one-pot two-step esterification–cyclization toward 3-aryl coumarins and 3-aryl-4-methylcoumarins is reported. The reaction of a variety of aryl acetic acids containing steric or reactive group with 2-hydroxybenzaldehydes or 2′-hydroxyacetophenone proceeded smoothly at room temperature to afford the corresponding products in good to excellent yields using inexpensive and readily available reactants and reagents.

Supporting Information