Synthesis 2017; 49(14): 3112-3117
DOI: 10.1055/s-0036-1588785
paper
© Georg Thieme Verlag Stuttgart · New York

An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates

Yevhenii M. Sokolenkoa, b, Eugeniy N. Ostapchuka, b, Artem Artemenkob, Oleksandr O. Grygorenko*a
  • aTaras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01601, Ukraine
  • bEnamine Ltd., Alexandra Matrosova Street 23, Kyiv 01103, Ukraine   Email: gregor@univ.kiev.ua
Further Information

Publication History

Received: 02 February 2017

Accepted after revision: 21 March 2017

Publication Date:
13 April 2017 (eFirst)

Abstract

An approach to 3-oxa-7-azabicyclo[3.3.0]octanes, bicyclic morpholine analogues, is reported, which relies on [3+2] cycloaddition of maleic anhydrides or furan-2(5H)-ones and an in situ generated azomethine ylide. The utility of the method was demonstrated on a multigram scale.

Supporting Information

 
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