Synlett 2017; 28(12): 1478-1480
DOI: 10.1055/s-0036-1588782
© Georg Thieme Verlag Stuttgart · New York

N-Triflylphosphorimidoyl Trichloride: A Versatile Reagent for the Synthesis of Strong Chiral Brønsted Acids

Sunggi Lee, Philip S. J. Kaib, Benjamin List*
  • Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email:
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Publication History

Received: 24 February 2017

Accepted after revision: 19 March 2017

Publication Date:
11 April 2017 (eFirst)


A series of strong Brønsted acids has been synthesized in high yields using N-triflylphosphorimidoyl trichloride as reagent. The syntheses proceed efficiently with electron-rich, electron-deficient, and sterically hindered substrates.

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