Iron-Catalyzed Carbenoid Insertion into C(sp3)–H Bonds
Received: 15 December 2016
Accepted after revision: 19 February 2017
08 March 2017 (eFirst)
An iron-catalyzed carbenoid insertion into C–H bonds of alkanes was developed with high activity (turnover numbers up to 690 in a gram-scale experiment) and chemoselectivity. This non-heme iron-catalyzed C(sp3)–H insertion reaction provides an efficient strategy for C–H functionalization.