Synlett
DOI: 10.1055/s-0036-1588743
letter
© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed Carbenoid Insertion into C(sp3)–H Bonds

Qing-Qing Chenga, Ji-Min Yanga, Huan Xua, Shou-Fei Zhu*a, b
  • aState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. of China
  • bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, P. R. of China   Email: sfzhu@nankai.edu.cn
Further Information

Publication History

Received: 15 December 2016

Accepted after revision: 19 February 2017

Publication Date:
08 March 2017 (eFirst)

Abstract

An iron-catalyzed carbenoid insertion into C–H bonds of alkanes was developed with high activity (turnover numbers up to 690 in a gram-scale experiment) and chemoselectivity. This non-heme iron-catalyzed C(sp3)–H insertion reaction provides an efficient strategy for C–H functionalization.

Supporting Information