Amine-Catalyzed Three-Component Cascade Reaction between Alcohols or Thiols, Activated Alkenes, and Enones: A Simple and Chemoselective Synthesis of Densely Functionalized Compounds

Abstract

A highly chemoselective three-component cascade reaction among alcohols or thiols, electron-deficient alkenes, and α,β-unsaturated ketones takes place under the catalysis of triethylamine, providing densely functionalized chain products in 44–99% yields. The transformation presumably proceeds through a sequential cascade of hetero-Michael/Michael reactions.

Key words

multicomponent reactions - hetero-Michael addition - alcohols - thiols - alkenes - enones

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