Synlett 2017; 28(01): 12-18
DOI: 10.1055/s-0036-1588669
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© Georg Thieme Verlag Stuttgart · New York

Synthesis of Emindole SB

David T. George, Eric J. Kuenstner, Sergey V. Pronin*
  • Department of Chemistry, University of California, Irvine, CA 92697-2025, USA   Email: spronin@uci.edu
Further Information

Publication History

Received: 23 September 2016

Accepted after revision: 15 November 2016

Publication Date:
23 November 2016 (eFirst)

Abstract

Paxilline indole diterpenes have been a subject of scientific inquiry for over 30 years due to their diverse biological activities and unique structural features. These efforts resulted in a multitude of synthetic approaches and a dozen completed synthesis. Here, we discuss our contributions to this area that culminated in an 11-step synthesis of (±)-emindole SB.

 
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