Synlett 2017; 28(01): 19-23
DOI: 10.1055/s-0036-1588643
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© Georg Thieme Verlag Stuttgart · New York

Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight

Quentin Lefebvre*
a   Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany
b   Université de Reims Champagne–Ardenne Institut de Chimie Moléculaire de Reims (UMR 6229), Equipe de Photochimie, UFR Sciences, 51687 Reims, France   eMail: quentin.lefebvre@ens-lyon.org
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Publikationsverlauf

Received: 23. September 2016

Accepted after revision: 12. Oktober 2016

Publikationsdatum:
07. November 2016 (online)


Dedicated to Dr. Bernard Langlois

Abstract

Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF3 radical.

1. Introduction

2. Transition-Metal-Free Activation of Sodium Triflinate

3. Photochemical Activation of Sodium Triflinate

4. Conclusions and Outlook

 
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