Synlett 2017; 28(01): 19-23
DOI: 10.1055/s-0036-1588643
© Georg Thieme Verlag Stuttgart · New York

Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight

Quentin Lefebvre*a, b
  • aInstitute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany
  • bUniversité de Reims Champagne–Ardenne Institut de Chimie Moléculaire de Reims (UMR 6229), Equipe de Photochimie, UFR Sciences, 51687 Reims, France   Email:
Further Information

Publication History

Received: 23 September 2016

Accepted after revision: 12 October 2016

Publication Date:
07 November 2016 (eFirst)

Dedicated to Dr. Bernard Langlois


Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF3 radical.

1. Introduction

2. Transition-Metal-Free Activation of Sodium Triflinate

3. Photochemical Activation of Sodium Triflinate

4. Conclusions and Outlook