A Rh(III)-Catalyzed Cascade C–H Functionalization/C(sp³)–C(sp³) Formation/Cyclization Reaction for the Synthesis of Isoquinolinedione Derivatives

Abstract

A cascade C–H functionalization/C(sp³)–C(sp³) formation/cyclization reaction of N-methoxybenzamides with diazomal­onates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp²)–C(sp³) and C(sp³)–C(sp³) bonds by rhodium(III) catalysis is also proposed.

Key words

cascade - C–H functionalization - C(sp³)–C(sp³) bond - rhodium(III) catalysis - synthesis

• References


For reviews on C–H functionalizations by metal carbene insertions, see:
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