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Synthesis 2017; 49(09): 2063-2073
DOI: 10.1055/s-0036-1588120
DOI: 10.1055/s-0036-1588120
paper
Regiospecific Synthesis of 5- and 6-Acylated Naphtho[1,2-b]benzofurans via Intramolecular Alkyne Carbonyl Metathesis
Further Information
Publication History
Received: 25 October 2016
Accepted after revision: 21 November 2016
Publication Date:
15 December 2016 (online)
Abstract
Straightforward access to various 5- and 6-acylated naphtho[1,2-b]benzofurans was achieved by successive Sonogashira coupling and intramolecular alkyne carbonyl metathesis to assemble the central aromatic C ring of naphtho[1,2-b]benzofurans regiospecifically substituted with an acyl group at the C5 or C6 position.
Key words
naphtho[1,2-b]benzofuran - Sonogashira coupling - alkyne carbonyl metathesis - intramolecular reaction - regiospecific reactionSupporting Information
- Supporting Information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588120. 1H and 13C NMR spectra of synthesized compounds are included.
- Supporting Information
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