Synthesis 2017; 49(07): 1675-1679
DOI: 10.1055/s-0036-1588115
paper
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Decarboxylative Cross-Coupling of 1,3,4-Oxa­diazoles with Alkynoic Acids: A Simple Route for the Preparation of 2-Alkynylated 1,3,4-Oxadiazoles

L. Madhava Reddy
a  Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, 500007, India   Email: krreddych.ou@gmail.com
,
P. Raghavendar Reddy
b  Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India
,
Ch. Krishna Reddy*
a  Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, 500007, India   Email: krreddych.ou@gmail.com
› Author Affiliations
Further Information

Publication History

Received: 07 September 2016

Accepted after revision: 11 November 2016

Publication Date:
15 December 2016 (online)


Abstract

For the first time 2-alk-1-ynyl-5-(het)aryl-1,3,4-oxadiazole derivatives have been synthesized by the decarboxylative cross-coupling of alk-2-ynoic acids with 2-(het)aryl-1,3,4-oxadiazoles, employing palladium(II) chloride as the catalyst and silver(I) oxide as an oxidant with 1,3-bis(diphenylphosphanyl)propane as a ligand. Products were formed in high yields with no byproduct.

 
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