Synlett 2017; 28(12): 1441-1444
DOI: 10.1055/s-0036-15588166
© Georg Thieme Verlag Stuttgart · New York

A Copper-Catalyzed Synthesis of Functionalized Quinazolines from Isocyanides and Aniline Tri- and Dichloroacetonitrile Adducts through Intramolecular C–H Activation

Manijeh Nematpoura, Elham Rezaeea, Sayyed Abbas Tabatabai*a, Mehdi Jahanib
  • aDepartment of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran   Email:
  • bDepartment of Chemistry, Sharif University of Technology, Tehran, Iran
Further Information

Publication History

Received: 08 January 2017

Accepted after revision: 08 March 2017

Publication Date:
11 April 2017 (eFirst)


A novel class of substituted quinazolines were prepared in good yields by a one-pot three-component reaction of isocyanides with adducts of anilines and tri- or dichloroacetonitrile, followed by intramolecular C–H activation, catalyzed by copper(I) iodide with l-proline as a ligand in acetonitrile at room temperature.

Supporting Information