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Synthesis 2016; 48(23): 4099-4109
DOI: 10.1055/s-0035-1562532
DOI: 10.1055/s-0035-1562532
paper
Controlled Generation of 3-Triflyloxyarynes
Authors
Further Information
Publication History
Received: 25 June 2016
Accepted after revision: 15 July 2016
Publication Date:
24 August 2016 (online)
Abstract
The efficient generation of 3-triflyloxyarynes, including those bearing a transformable group, through an iodine–magnesium exchange reaction of 1,3-bis(triflyloxy)-2-iodoarenes was achieved by using finely tuned reaction conditions that efficiently suppressed the competing thia-Fries rearrangement. The method enabled the facile synthesis of a wide range of multisubstituted arenes.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562532.
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For some recent reviews on arynes, see:
For some recent aryne chemistries, see: