Synthesis 2016; 48(23): 4189-4198
DOI: 10.1055/s-0035-1562457
paper
© Georg Thieme Verlag Stuttgart · New York

The Concept of Sequential Multicomponent Reactions: A Short Synthesis of Thiazolo- and Oxazolo[1,4]benzodiazepine-2,5-diones

Denis Kröger
Institut für Chemie, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Timo Stalling
Institut für Chemie, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Jürgen Martens*
Institut für Chemie, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 25 April 2016

Accepted after revision: 06 June 2016

Publication Date:
13 July 2016 (online)


Abstract

A new synthetic sequence including two sequential multicomponent reactions leading to a wide range of thiazolo- and oxazolo-annulated benzodiazepinediones is described. This strategy features simple one-pot operations under mild conditions in combination with a high degree of diversity, and can be realized based on commercially available or easily accessible starting materials.

Supporting Information

 
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