Diastereoselective Gold(I)-Catalyzed [2+2+2] Cycloaddition of Oxo-1,5-enynes

^‡ These authors contributed equally.

In memory of Professor Jean Normant.

Abstract

The intramolecular gold(I)-catalyzed [2+2+2] cycloaddition of oxo-1,5-enynes bearing protected homopropargylic alcohols provides access to oxatricyclic adducts with good to excellent diastereoselectivity.

Key words

gold - enynes - cycloisomerization - cycloaddition - Prins reaction

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