Synlett 2016; 27(13): 1973-1978
DOI: 10.1055/s-0035-1561630
letter
© Georg Thieme Verlag Stuttgart · New York

Nickel(II)-Catalyzed Asymmetric Michael Addition of Oxindoles with Modified N,N,O-Tridentate Chiral Phenanthroline Ligands

Yuki Naganawa*, Hiroki Abe, Hisao Nishiyama*
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Publication History

Received: 03 March 2016

Accepted after revision: 04 April 2016

Publication Date:
10 May 2016 (eFirst)

Abstract

Nickel(II)-catalyzed enantioselective Michael addition of N-Boc-oxindole derivatives with methyl vinyl ketone was demonstrated to give the corresponding adducts having chiral all-carbon quaternary centers with up to 87% ee in the presence of axially chiral N,N,O-tridentate phenanthroline ligand.

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