Synthesis of Novel Imidazopyrrolo-Fused Isoxazole Derivatives through Acid-Mediated Intramolecular 1,3-Dipolar Cycloaddition

Abstract

A facile approach to 4H-imidazo[1′,2′:1,2]pyrrolo[3,4-c]isoxazole derivatives was developed via intramolecular 1,3-dipolar cycloaddition catalyzed by p-toluenesulfonic acid. The method allows the convenient construction of novel tricyclic isoxazoles under mild reaction conditions and moderate yields.

Key words

1,3-dipolar cycloaddition - 2-nitro-1,1-ethenediamine - nitromethylene-imidazolidine - p-toluenesulfonic acid - tricyclic isoxazoles

• References

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