Three-Component Reaction for the Convenient Synthesis of Functionalized 3-{1-[2-(1H-Indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones

Abstract

A simple synthetic protocol was developed for the efficient synthesis of functionalized 3-{1-[2-(1H-indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones in high yield via three-component reaction of tryptamine, dimedone, and 3-phenacylideneoxindoles in refluxing acetonitrile with p-toluenesulfonic acid as catalyst.

Key words

multicomponent reaction - β-enaminone - tryptamine - isa­tin - dimedone - indole

• References

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