Synthesis 2016; 48(04): 535-540
DOI: 10.1055/s-0035-1560965
paper
© Georg Thieme Verlag Stuttgart · New York

Rapid Synthesis of Functionalized (1-Benzo[d]thiazol-2-ylimidazolidin-4-ylidene)acetates and (1-Thiazol-2-ylimidazolidin-4-ylid­ene)acetates via a Three-Component Reaction

Jing Zhang
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China   Email: cgyan@yzu.edu.cn
,
Chao-Guo Yan*
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China   Email: cgyan@yzu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 24 July 2015

Accepted after revision: 23 October 2015

Publication Date:
11 January 2016 (online)


Abstract

A simple synthetic protocol was developed for the efficient synthesis of functionalized (1-benzo[d]thiazol-2-ylimidazolidin-4-ylidene)acetates via a three-component reaction among 2-aminobenzothiazole, α,β-unsaturated N-arylaldimines, and dialkyl acetylenedicarboxylates in anhydrous dichloromethane at room temperature. Additionally, the three-component reaction with 2-aminothiazole afforded the corresponding (1-thiazol-2-ylimidazolidin-4-ylidene)acetates.

Supporting Information

 
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