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Synthesis 2016; 48(03): 437-440
DOI: 10.1055/s-0035-1560534
DOI: 10.1055/s-0035-1560534
paper
An Eco-friendly, Hantzsch-Based, Solvent-Free Approach to 2-Aminothiazoles and 2-Aminoselenazoles
Further Information
Publication History
Received: 01 September 2015
Accepted after revision: 15 October 2015
Publication Date:
03 December 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201603/lookinside/thumbnails/ss-2015-m0436-op_10-1055_s-0035-1560534-1.jpg)
Abstract
We report a simple, fast, and eco-friendly solvent-free protocol for the synthesis of 2-aminothiazoles and 2-amino-1,3-selenazoles (16 examples) through Hantzsch condensation without the use of a catalyst. It is noteworthy that this type of procedure is unprecedented for the synthesis of 1,3-selenazoles. Reactions proceed to completion in a few seconds and products are obtained in moderate to excellent yields after easy workup. Moreover, the synthesis of 4-(2-amino-1,3-selenazol-4-yl)benzonitrile hydrobromide is reported for the first time.
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