Synthesis 2015; 47(24): 3963-3971
DOI: 10.1055/s-0035-1560199
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cyclopropyl- and Cyclobutylpiperidines: Advanced Building Blocks for Drug Discovery

Ivan I. Vyzir
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
b   National Technical University of Ukraine ‘Kyiv Polytechnic Institute’, 37 Peremohy ave., 03056, Kyiv, Ukraine
,
Rustam T. Iminov
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
,
Anton Tverdokhlebov*
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
,
Andrey A. Tolmachev
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
c   Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Andriy V. Shcherbatiuk
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
c   Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Pavel K. Mykhailiuk*
a   Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   eMail: A.tverdohlebov@mail.enamine.net   eMail: Pavel.Mykhailiuk@mail.enamine.net   eMail: Pavel.Mykhailiuk@gmail.com
c   Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Angelina V. Biitseva
c   Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
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Weitere Informationen

Publikationsverlauf

Received: 19. Juni 2015

Accepted after revision: 04. August 2015

Publikationsdatum:
08. September 2015 (online)


Dedicated to the 25th anniversary of Enamine Ltd.

Abstract

A library of cyclopropyl- and cyclobutylpiperidine derivatives were synthesized from commonly available starting materials through Wittig reactions.

Supporting Information

 
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