Synthesis 2015; 47(24): 3963-3971
DOI: 10.1055/s-0035-1560199
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cyclopropyl- and Cyclobutylpiperidines: Advanced Building Blocks for Drug Discovery

Ivan I. Vyzir
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
b  National Technical University of Ukraine ‘Kyiv Polytechnic Institute’, 37 Peremohy ave., 03056, Kyiv, Ukraine
,
Rustam T. Iminov
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
,
Anton Tverdokhlebov*
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
,
Andrey A. Tolmachev
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
c  Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Andriy V. Shcherbatiuk
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
c  Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Pavel K. Mykhailiuk*
a  Enamine Ltd., 78 Chervonotkatska str., 02094, Kyiv, Ukraine   Email: A.tverdohlebov@mail.enamine.net   Email: Pavel.Mykhailiuk@mail.enamine.net   Email: Pavel.Mykhailiuk@gmail.com
c  Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
,
Angelina V. Biitseva
c  Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska str., 01601, Kyiv, Ukraine
› Author Affiliations
Further Information

Publication History

Received: 19 June 2015

Accepted after revision: 04 August 2015

Publication Date:
08 September 2015 (eFirst)

Dedicated to the 25th anniversary of Enamine Ltd.

Abstract

A library of cyclopropyl- and cyclobutylpiperidine derivatives were synthesized from commonly available starting materials through Wittig reactions.

Supporting Information

 
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