A New Analogue of Locked Cyclohexane Nucleic Acids

Abstract

We report on a new analogue of locked cyclohexane nucleic acids that contains an adenine nucleobase at an alternative position and which resembles homo-DNA. The crucial locked carbocyclic nucleo­side monomer was prepared with high enantioselectivity and was subsequently incorporated into a pair of modified oligonucleotides that were subjected to hybridization studies.

Key words

nucleosides - bicyclic compounds - oligonucleotides - carbocycles - medicinal chemistry

• References

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