Synthesis 2015; 47(11): 1643-1655
DOI: 10.1055/s-0034-1380185
paper
© Georg Thieme Verlag Stuttgart · New York

Novel One-Pot Multicomponent Strategy for the Synthesis of Pyrrolo[1,2-a]benzimidazole and Pyrrolo[1,2-a]quinoxaline Derivatives

Emilian Georgescu
a  Research Center Oltchim, St. Uzinei 1, 240050 Ramnicu Valcea, Romania
,
Alina Nicolescu
b  ‘C. D. Nenitescu’ Centre of Organic Chemistry, Academia Română, Spl. Independentei 202-B, 060023 Bucharest, Romania
c  ‘Petru Poni’ Institute of Macromolecular Chemistry, Academia Română, Aleea Grigore Ghica Voda 41-A, 700487 Iasi, Romania   Email: calin.deleanu@yahoo.com
,
Florentina Georgescu
d  Research Dept., Teso Spec S.R.L., Str. Muncii 53, 915200 Fundulea, Calarasi, Romania
,
Sergiu Shova
c  ‘Petru Poni’ Institute of Macromolecular Chemistry, Academia Română, Aleea Grigore Ghica Voda 41-A, 700487 Iasi, Romania   Email: calin.deleanu@yahoo.com
e  Institute of Chemistry, Academy of Sciences, Str. Academiei 3, 2028 Chisinau, Republic of Moldova
,
Florina Teodorescu
b  ‘C. D. Nenitescu’ Centre of Organic Chemistry, Academia Română, Spl. Independentei 202-B, 060023 Bucharest, Romania
,
Ana-Maria Macsim
c  ‘Petru Poni’ Institute of Macromolecular Chemistry, Academia Română, Aleea Grigore Ghica Voda 41-A, 700487 Iasi, Romania   Email: calin.deleanu@yahoo.com
,
Calin Deleanu*
b  ‘C. D. Nenitescu’ Centre of Organic Chemistry, Academia Română, Spl. Independentei 202-B, 060023 Bucharest, Romania
c  ‘Petru Poni’ Institute of Macromolecular Chemistry, Academia Română, Aleea Grigore Ghica Voda 41-A, 700487 Iasi, Romania   Email: calin.deleanu@yahoo.com
› Author Affiliations
Further Information

Publication History

Received: 24 January 2015

Accepted after revision: 02 February 2015

Publication Date:
05 March 2015 (online)


Abstract

A simple one-pot multicomponent procedure has been developed for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives by heating a 1:2:1 molar mixture of a benzimidazole unsubstituted on the imidazole ring, a 2-bromoacetophenone derivative, and a nonsymmetrical activated alkyne in refluxing 2-ethyloxirane. The reaction can be performed under conventional reflux conditions or with microwave irradiation.

Supporting Information

Primary Data

 
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