On the Importance of the Relative Stereochemistry of Substituents in the Formation of Nine-Membered Lactones by Ring-Closing Metathesis

Abstract

The effects of isopropyl substituents and molar concentration of diastereomeric esters toward the formation of nine-membered unsaturated lactones, in the context of the synthesis of the intermediates of the antihypertensive drug aliskiren, have been studied.

Key words

lactone - metathesis - cyclization - macrocycle - dimerization

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