Synthesis 2015; 47(09): 1317-1324
DOI: 10.1055/s-0034-1380130
paper
© Georg Thieme Verlag Stuttgart · New York

On the Importance of the Relative Stereochemistry of Substituents in the Formation of Nine-Membered Lactones by Ring-Closing Metathesis

Jean-Philippe Cusson
Department of Chemistry, Université de Montréal, CP6128 Succursale A, Centre-ville, Montréal, Québec, H3C 3J7, Canada   Email: stephen.hanessian@umontreal.ca
,
Etienne Chénard
Department of Chemistry, Université de Montréal, CP6128 Succursale A, Centre-ville, Montréal, Québec, H3C 3J7, Canada   Email: stephen.hanessian@umontreal.ca
,
Stephen Hanessian*
Department of Chemistry, Université de Montréal, CP6128 Succursale A, Centre-ville, Montréal, Québec, H3C 3J7, Canada   Email: stephen.hanessian@umontreal.ca
› Author Affiliations
Further Information

Publication History

Received: 26 November 2014

Accepted after revision: 02 January 2015

Publication Date:
19 February 2015 (eFirst)

Abstract

The effects of isopropyl substituents and molar concentration of diastereomeric esters toward the formation of nine-membered unsaturated lactones, in the context of the synthesis of the intermediates of the antihypertensive drug aliskiren, have been studied.

Supporting Information

 
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