Synthesis 2015; 47(05): 726-736
DOI: 10.1055/s-0034-1379975
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed One-Pot Synthesis of α-Ketoamides from 1-Arylethanols

Nidhi Sharma
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India   Email: gsekar@iitm.ac.in
,
Surya Srinivas Kotha
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India   Email: gsekar@iitm.ac.in
,
Nabajit Lahiri
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India   Email: gsekar@iitm.ac.in
,
Govindasamy Sekar*
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India   Email: gsekar@iitm.ac.in
› Author Affiliations
Further Information

Publication History

Received: 14 November 2014

Accepted after revision: 15 December 2014

Publication Date:
28 January 2015 (eFirst)

Abstract

A copper-catalyzed one-pot strategy for the synthesis of α-ketoamides from 1-arylethanols is described. This triple oxidation of 1-arylethanols involves alcohol oxidation, sp3 C–H oxidation, and oxidative amidation with amines. The protocol is highly efficient, delivering α-ketoamides in good to excellent yields.

Supporting Information

 
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