Synthesis 2015; 47(05): 701-711
DOI: 10.1055/s-0034-1379639
paper
© Georg Thieme Verlag Stuttgart · New York

Three-Component Domino Heteroannulation and Synthesis of Some Novel Hexahydropyrimido[4,5-b]-1,8-naphthyridine Derivatives

P. Seetham Naidu*
Medicinal Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India   Email: pulak_jyoti@yahoo.com
,
Sinki Kolita
Medicinal Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India   Email: pulak_jyoti@yahoo.com
,
Swarup Majumder
Medicinal Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India   Email: pulak_jyoti@yahoo.com
,
Pulak J. Bhuyan*
Medicinal Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India   Email: pulak_jyoti@yahoo.com
› Author Affiliations
Further Information

Publication History

Received: 03 September 2014

Accepted after revision: 17 November 2014

Publication Date:
05 January 2015 (eFirst)

Abstract

An efficient protocol has been developed for the synthesis of some novel hexahydropyrimido[4,5-b]-1,8-naphthyridine derivatives by a one-pot three-component reaction of a 2-cyano-3-(1H-indol-3-yl)-pent-2-enedinitrile or ethyl-2,4-dicyano-3-(1H-indol-3-yl)but-2-enoate derivative with an aryl aldehyde and a 6-aminouracil derivative. The indole derivatives were prepared by the reaction of the corresponding 3-(cyanoacetyl)indoles with acetonitrile derivatives.

Supporting Information

 
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