Towards Tris(diimine)–Ruthenium(II) and Bis(quinoline)–Re(I)(CO)₃ Complexes as Photoactivated Anticancer Drug Candidates

Abstract

The clinical success of cisplatin continues to inspire the development of metal-based anticancer drug candidates. This article is meant to present the current state-of-the-art and science of ruthenium(II)- and rhenium(I)-based anticancer drug candidates born out of our work in this field. Our recent efforts to elicit photoactivation of intact (organo)metallic anticancer drug candidates as a promising way for commanding their activity within cancer cells are also briefly summarized.

1 Introduction

2 Ruthenium(II) Complexes

3 Rhenium(I) Complexes

4 Concluding Remarks

Key words

antitumor agents - carbonyl complexes - drugs - medicinal chemistry - ruthenium - photochemistry

• References and Notes

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