Synthesis 2015; 47(02): 181-186
DOI: 10.1055/s-0034-1379206
paper
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides in Water

Authors

  • Yi-An Chen

  • Satpal Singh Badsara

  • Wan-Ting Tsai

  • Chin-Fa Lee*

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Publikationsverlauf

Received: 26. Juli 2014

Accepted after revision: 01. September 2014

Publikationsdatum:
15. Oktober 2014 (online)


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Abstract

Microwave-promoted C–S bond formation from thiols and aryl iodides in the presence of a copper catalyst is reported. A combination of copper(II) oxide and 1,10-phenanthroline catalyzes this reaction. A variety of aryl iodides react smoothly with thiols to provide the corresponding aryl sulfides in good to excellent yields. Notably, the reactions proceed in water with a short reaction time (30 minutes). This system shows broad functional-group tolerance; amino, chloro, bromo, acetyl, and nitro groups are unaffected by the reaction conditions.

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