Synlett 2014; 25(18): 2644-2648
DOI: 10.1055/s-0034-1379101
© Georg Thieme Verlag Stuttgart · New York

The Catalytic Synthesis of Carboniolamide: The Role of sp 3 Hybridized Oxygen

Yi Zhanga, Yuchi Daia, Guigen Lia, b, Xu Cheng*a
  • aInstitute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. of China
  • bDepartment of Chemistry and Biochemistry, Texas Tech University, Memorial Circle & Boston, Lubbock, TX 79409-1061, USA   Fax: +86(25)84687372   Email:
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Publication History

Received: 19 July 2014

Accepted after revision: 18 August 2014

Publication Date:
17 September 2014 (eFirst)


A catalytic synthesis of carboniolamide has been reported. The strategy was straightforward with aldehyde and amide as starting materials. The products can be isolated as precipitates from the reaction mixture. The factor that stabilizes the labile functionality of hemiaminal was elucidated as a sp 3 hybridized oxygen.

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