Synlett 2014; 25(20): 2923-2927
DOI: 10.1055/s-0034-1378913
letter
© Georg Thieme Verlag Stuttgart · New York

TEMPO/NBu4Br-Catalyzed Selective Alcohol Oxidation with Periodic Acid

Mariam Attoui
,
Jean-Michel Vatèle*
Further Information

Publication History

Received: 15 September 2014

Accepted: 02 October 2014

Publication Date:
29 October 2014 (eFirst)

Abstract

Oxidation of primary and secondary alcohols, using catalytic amounts of TEMPO and tetra-n-butylammonium bromide in combination with periodic acid and wet alumina in dichloromethane is described. This oxidizing system is compatible with a broad range of functional groups and acid-sensitive protecting groups. Chemoselective oxidation of secondary alcohols in the presence of primary alcohols was observed.

 
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