Copper(II) Triflate Catalyzed Synthesis of 2,4-Disubstituted Oxazoles from α-Diazoketones

Abstract

A novel method is devised for the synthesis of 2,4-disubstituted oxazole derivatives via the coupling of α-diazoketones with amides using copper(II) triflate as the catalyst. The synthetic versatility of this approach is exemplified in the synthesis of an analogue of balsoxin.

Key words

α-diazoketones - amides - copper(II) triflate - oxazoles

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