A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine

Abstract

Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et₃N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields.

Key words

2-fluoromalonic esters - 2-chloromalonic esters - hydrogen fluoride - hydrochloric acid - iodosylbenzene

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