A Concise Total Synthesis of (±)-Cassumunin C

Abstract

The first concise and efficient total synthesis of (±)-cassumunin C has been accomplished with a longest linear sequence of seven steps in 11.7% yield. The key steps involve aromatic propargylation and stereoselective reduction of alkynylphenol to the corresponding (E)-alkenylphenol.

Key words

aldol condensation - aromatic propargylation - Reimer–Tiemann reaction - lithium aluminum hydride - natural product

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