Synthesis 2014; 46(22): 3059-3066
DOI: 10.1055/s-0034-1378541
paper
© Georg Thieme Verlag Stuttgart · New York

A Novel N-Benzylation of Phenothiazine with Benzyl Alcohols Activated by n-Propylphosphonic Acid Anhydride (T3P®)

Lucilla Levi
Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany   Fax: +49(211)8114324   Email: ThomasJJ.Mueller@uni-duesseldorf.de
,
Sven Scheuren
Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany   Fax: +49(211)8114324   Email: ThomasJJ.Mueller@uni-duesseldorf.de
,
Thomas J. J. Müller*
Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany   Fax: +49(211)8114324   Email: ThomasJJ.Mueller@uni-duesseldorf.de
› Author Affiliations
Further Information

Publication History

Received: 11 June 2014

Accepted after revision: 28 June 2014

Publication Date:
13 August 2014 (eFirst)

Abstract

Phenothiazine readily undergoes N-benzylation with benzyl alcohols by in situ activation with T3P® (propylphosphonic acid anhydride) in a straightforward fashion and with good to excellent yields.

Supporting Information

 
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