A Novel N-Benzylation of Phenothiazine with Benzyl Alcohols Activated by n-Propylphosphonic Acid Anhydride (T3P®)

Lucilla Levi; Sven Scheuren; Thomas J. J. Müller

doi:10.1055/s-0034-1378541

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(22): 3059-3066
DOI: 10.1055/s-0034-1378541

paper

A Novel N-Benzylation of Phenothiazine with Benzyl Alcohols Activated by n-Propylphosphonic Acid Anhydride (T3P^®)

Lucilla Levi

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany Fax: +49(211)8114324 eMail: ThomasJJ.Mueller@uni-duesseldorf.de

,

Sven Scheuren

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany Fax: +49(211)8114324 eMail: ThomasJJ.Mueller@uni-duesseldorf.de

,

Thomas J. J. Müller*

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany Fax: +49(211)8114324 eMail: ThomasJJ.Mueller@uni-duesseldorf.de

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Abstract

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Abstract

Phenothiazine readily undergoes N-benzylation with benzyl alcohols by in situ activation with T3P^® (propylphosphonic acid anhydride) in a straightforward fashion and with good to excellent yields.

Key words

alcohol activation - benzyl alcohols - nucleophilic substitution - phenothiazine - tertiary amine

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Referenzen

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