Synlett 2014; 25(14): 2033-2035
DOI: 10.1055/s-0034-1378361
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 2-Alkynyl 1,3,4-Oxadiazoles by Palladium-Catalyzed Cross- Coupling Reaction[1]

N. Salvanna
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Fax: +91(40)27160512   eMail: biswanathdas@yahoo.com
,
Biswanath Das*
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Fax: +91(40)27160512   eMail: biswanathdas@yahoo.com
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Publikationsverlauf

Received: 15. April 2014

Accepted after revision: 30. Mai 2014

Publikationsdatum:
16. Juli 2014 (online)


Abstract

Several 2-alkynyl 1,3,4-oxadiazoles have been synthesized efficiently by employing palladium-catalyzed cross-coupling under Sonogashira reaction conditions. This reaction has been applied for the first time for the preparation of oxadiazole derivatives. The products were formed in high yields and no side products were detected.

 
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