Thorac Cardiovasc Surg 2015; 63(01): 002-020
DOI: 10.1055/s-0034-1378191
Review Article
Georg Thieme Verlag KG Stuttgart · New York

The Predictive Value of Platelet Function Point-of-Care Tests for Postoperative Blood Loss and Transfusion in Routine Cardiac Surgery: A Systematic Review

Mate Petricevic
1  Department of Cardiac Surgery, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Tomislav Kopjar
1  Department of Cardiac Surgery, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Bojan Biocina
1  Department of Cardiac Surgery, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Davor Milicic
2  Department of Cardiovascular Diseases, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Kresimir Kolic
3  Department of Medical Diagnostics, University of Split School of Medicine—University Hospital Center Split, Split, Croatia
,
Marko Boban
4  Department of Cardiology, University Hospital “Thalassotherapia Opatija,” Medical School University of Rijeka and Osijek, Opatija, Croatia
,
Bosko Skoric
2  Department of Cardiovascular Diseases, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Ante Lekic
1  Department of Cardiac Surgery, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
,
Hrvoje Gasparovic
1  Department of Cardiac Surgery, University of Zagreb School of Medicine—University Hospital Center Zagreb, Zagreb, Croatia
› Author Affiliations
Further Information

Publication History

15 October 2013

14 March 2014

Publication Date:
01 July 2014 (online)

Abstract

Excessive bleeding after cardiopulmonary bypass (CPB) operations remains to be a persistent problem and weak platelet function certainly contributes to bleeding diathesis. Antiplatelet therapy (APT) is an integral component of perioperative management in patients undergoing cardiac surgery procedures, both with and without use of CPB. In addition to individual variability in platelet function, different preoperative APT administration/discontinuation management further affects platelet function, which in turn may reflect bleeding tendency. However, the impact of drug-induced platelet inhibition on early postoperative bleeding extent remains difficult to predict. Herein, we reviewed the available evidence on the association between platelet function testing values and the extent of bleeding and transfusion requirements in early perioperative period. Currently, the association between platelet function measured by ex vivo assay and the occurrence of bleeding events remains uncertain. The intent of this review is to provide comprehensive literature insight into published evidence, investigating the possibility of platelet function tests to predict bleeding extent as well as transfusion requirements in cardiac surgery patients.