Maternal Glucose Response to Betamethasone Administration
01 November 2013
03 April 2014
10 June 2014 (online)
Objective This study aims to describe the pattern of maternal glucose response to betamethasone administration using a continuous glucose monitoring system.
Study Design A prospective observational trial was conducted among women receiving clinically indicated betamethasone between 24 and 34 weeks gestation. At the time of initial betamethasone administration, a continuous glucose monitoring device was inserted which measured interstitial fluid glucose levels every 5 minutes. Glucose levels were monitored for 7 days, until delivery, or until hospital discharge, whichever came first. We recorded the percentage of time women spent above three glucose thresholds: 110, 144, and 180 mg/dL, respectively.
Results A total of 17 women were enrolled at the time of betamethasone administration and data were available for 15 patients. There were 11 nondiabetic and 4 diabetic women. Both diabetic and nondiabetic women had the highest recorded blood glucose readings between 24 and 48 hours after the first injection of betamethasone. In that period, nondiabetic women spent 73, 40, and 17% of the time with blood glucose levels above the 110, 144, and 180 mg/dL thresholds, respectively.
Conclusion Nondiabetic women receiving betamethasone manifest significant hyperglycemia after betamethasone administration. If delivery is imminent, maternal glucose response to betamethasone may need to be monitored to prevent possible neonatal hypoglycemia.
Dexcom provided the continuous glucose monitoring devices for this study. In addition, Drs. Sung, Taslimi, and El-Sayed were conducting an investigator initiated, industry-funded prospective trial involving the use of the Dexcom continuous glucose monitoring device in pregnant women. The authors have no other financial relationship with Dexcom. The authors have no other conflicts of interest. This article was presented at: 32nd Annual Meeting of the Society for Maternal-Fetal Medicine, February 6–11, 2012; Dallas, TX.
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