Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of 1,3-Diaryl­diketones To Synthesize 1,2-Diketones

Chun Zhang; Xiaoyang Wang; Ning Jiao

doi:10.1055/s-0033-1341243

Synlett, Table of Contents

Synlett 2014; 25(10): 1458-1460
DOI: 10.1055/s-0033-1341243

letter

Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of 1,3-Diaryldiketones To Synthesize 1,2-Diketones

Authors

Chun Zhang

^aState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, P. R. of China
Xiaoyang Wang

^aState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, P. R. of China
Ning Jiao*

^aState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, P. R. of China

^bState Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China Fax: +86(10)82805297 Email: jiaoning@bjmu.edu.cn

Abstract

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Abstract

An aerobic oxidative C–C bond cleavage of 1,3-diaryldiketones for the synthesis of 1,2-diketones by using O₂ as the oxidant has been developed. Control experiments illustrate that the copper catalyst not only assist the aerobic oxidative process of 1,3-diketones, but also catalyze the 1,2-Wagner–Meerwein-type rearrangement process.

Key words

copper - C–C bond cleavage - aerobic oxidative reaction - 1,2-diketones

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References

References and Notes

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Supplementary Material

Supporting Information (PDF)

Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of 1,3-Diaryl­diketones To Synthesize 1,2-Diketones

Authors

Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of 1,3-Diaryldiketones To Synthesize 1,2-Diketones