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Synthesis 2014; 46(07): 864-870
DOI: 10.1055/s-0033-1340868
DOI: 10.1055/s-0033-1340868
feature article
Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin
Authors
Further Information
Publication History
Received: 17 December 2013
Accepted after revision: 06 February 2014
Publication Date:
27 February 2014 (online)
Abstract
The first enantioselective catalytic total synthesis of (–)-pyridovericin is reported. The key steps involve a modified HWE reaction under aqueous conditions and an asymmetric iridium-catalyzed hydrogenation. This resulted in a highly modular and stereoselective approach that delivered the target natural product in high yield and stereoselectivity.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
Included are 1H and 13C NMR spectra and HPLC traces.
- Supporting Information (PDF)
-
References
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