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Synlett 2014; 25(6): 863-865
DOI: 10.1055/s-0033-1340848
DOI: 10.1055/s-0033-1340848
letter
The First Stereoselective Total Synthesis of the Immunosuppressive Decalin Derivative Monascusic Acid B[1]
Further Information
Publication History
Received: 06 December 2013
Accepted after revision: 30 January 2014
Publication Date:
06 March 2014 (online)
Abstract
The first stereoselective total synthesis of the immunosuppressive decalin derivative monascusic acid B has been accomplished from (R)-(+)-pulegone involving Horner–Wadsworth–Emmons and Julia–Kocienski olefination reactions and Lewis acid catalyzed intramolecular Diels–Alder cyclization.
Key words
monascusic acid B - total synthesis - (R)-(+)-pulegone - Horner–Wadsworth–Emmons olefination - Julia–Kocienski olefination - intramolecular Diels–Alder cyclization - immunosuppressive effectSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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References and Notes
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