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Synthesis 2014; 46(09): 1254-1260
DOI: 10.1055/s-0033-1340840
DOI: 10.1055/s-0033-1340840
paper
Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles
Further Information
Publication History
Received: 17 January 2014
Accepted: 29 January 2014
Publication Date:
18 February 2014 (online)
Abstract
Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
References
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Selected reviews:
For selected books, see:
For some reviews on the synthesis of pyrazoles and in particular trifluoromethyl-substituted pyrazoles, see:
For the recent examples, see: