Synthesis 2014; 46(09): 1254-1260
DOI: 10.1055/s-0033-1340840
paper
© Georg Thieme Verlag Stuttgart · New York

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

Dmytro V. Yarmoliuk
a  Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64, 01601 Kyiv, Ukraine   Fax: +389(44)2351273   Email: Pavel.Mykhailiuk@gmail.com
,
Viatcheslav V. Arkhipov
b  Enamine Ltd., Oleksandra Matrosova Street, 23, 01103 Kyiv, Ukraine
,
Maksym V. Stambirskyi
b  Enamine Ltd., Oleksandra Matrosova Street, 23, 01103 Kyiv, Ukraine
,
Yurii V. Dmytriv
b  Enamine Ltd., Oleksandra Matrosova Street, 23, 01103 Kyiv, Ukraine
,
Oleg V. Shishkin
c  STC, Institute for Single Crystals, National Academy of Science of Ukraine, 60 Lenina Ave., 61001 Kharkiv, Ukraine
,
Andrei A. Tolmachev
a  Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64, 01601 Kyiv, Ukraine   Fax: +389(44)2351273   Email: Pavel.Mykhailiuk@gmail.com
b  Enamine Ltd., Oleksandra Matrosova Street, 23, 01103 Kyiv, Ukraine
,
Pavel K. Mykhailiuk*
a  Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64, 01601 Kyiv, Ukraine   Fax: +389(44)2351273   Email: Pavel.Mykhailiuk@gmail.com
b  Enamine Ltd., Oleksandra Matrosova Street, 23, 01103 Kyiv, Ukraine
› Author Affiliations
Further Information

Publication History

Received: 17 January 2014

Accepted: 29 January 2014

Publication Date:
18 February 2014 (eFirst)

Abstract

Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.

Supporting Information

 
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