Synlett 2014; 25(6): 847-852
DOI: 10.1055/s-0033-1340736
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Mediated Cascade Synthesis of Diaryl Sulfones via the Sandmeyer Reaction

Xiaobo Yang*
a   College of Chemistry and Life Science, Shenyang Normal University, Shenyang, Liaoning 110034, P. R. of China   Email: bxy1223@gmail.com
,
Liangliang Shi
b   Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China   Fax: +86(10)62781695   Email: fuhua@mail.tsinghua.edu.cn
,
Hua Fu*
b   Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China   Fax: +86(10)62781695   Email: fuhua@mail.tsinghua.edu.cn
c   Key Laboratory of Chemical Biology (Guangdong Province), Graduate School of Shenzhen, Tsinghua University, Shenzhen 518057, P. R. of China
› Author Affiliations
Further Information

Publication History

Received: 09 December 2013

Accepted after revision: 15 January 2014

Publication Date:
05 March 2014 (online)


Abstract

A convenient and efficient method for the copper-mediated cascade synthesis of diaryl sulfones via the Sandmeyer reaction has been developed. The protocol uses readily available aryl amines and arylsulfinic acids as the starting materials, isoamyl nitrite as the diazotizating reagent of the aryl amines, and the method shows mild reaction conditions and high tolerance towards various functional groups in the substrates.

Supporting Information

 
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