A Robust Route towards Functionalized Pyrrolizidines as Precursors for Daphniphyllum Alkaloids

Abstract

A diastereoselective Fráter–Seebach-type alkylation provides access to a highly functionalized pyrrolizidine, which could serve as a key building block for the total synthesis of ­Daphniphyllum alkaloids, such as oldhamine A.

Key words

Daphniphyllum alkaloids - pyrrolizidines - hetero­cycles - asymmetric synthesis - oldhamine A

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