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Synlett 2014; 25(6): 760-765
DOI: 10.1055/s-0033-1340626
DOI: 10.1055/s-0033-1340626
synpacts
Intermolecular Ketene–Alkene [2+2] Cycloadditions: The Significance of Lewis Acid Promoted Variants
Further Information
Publication History
Received: 15 November 2013
Accepted after revision: 10 December 2013
Publication Date:
15 January 2014 (online)
Abstract
Ketene–alkene [2+2] cycloadditions are an important class of reactions for chemical synthesis. These processes were exclusively carried out under thermal conditions, which ultimately lead to limitations regarding scope and stereoselectivity. Reviewed herein are recently developed Lewis acid promoted ketene–alkene [2+2] cycloadditions that address several of the problems known to plague these reactions.
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For a recent example, see:
For examples, see:
For excellent reviews regarding ketene–alkene [2+2] cycloadditions, see:
For reviews, see:
For example, see:
For selected recent studies regarding the mechanism of ketene–alkene [2+2], see:
For lead references regarding dichloroketene, see:
For lead references regarding monochloro ketenes, see:
For examples, see:
Lewis acid promoted ketene–aldehyde [2+2] cycloadditions are known, however, these reactions are not only different with regard to mechanism but also product generated. For examples, see: