Synlett 2014; 25(1): 153-154
DOI: 10.1055/s-0033-1340155
© Georg Thieme Verlag Stuttgart · New York

Acetaldehyde: Use in Organocatalysis

Sun Min Kim
Department of Energy Science, Sungkyunkwan University, Suwon 440-746, Republic of Korea   Email:
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Publication History

Publication Date:
19 November 2013 (online)


Acetaldehyde is a small organic molecule and the simplest enolazable aldehyde. It is an important synthon for the construction of β-amino acid derivatives, α-hydroxy ketones, and so forth, if suitable reagents are employed. ­Despite this versatility, the use of acetaldehyde can be complicated due to its tendency to oligomerize or poly­merize.

Recently, several research groups reported the multifarious utility of acetaldehyde in many diverse asymmetric organocatalytic transformations by controlling the reactivity of acetaldehyde.[1] The reactions furnished the corresponding products in high yields with stereoselectivities. An overview of typical applications of acetaldehyde is shown in Scheme [1].

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Scheme 1 Versatile use of acetaldehyde in asymmetric organocatalysis
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