Synthesis 2014; 46(03): 290-294
DOI: 10.1055/s-0033-1340106
practical synthetic procedures
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 1,2-Dimetallic Compounds via Direct Insertion of Zinc Powder in the Presence of InCl3: Synthesis of ortho-Bis-functionalized Aromatics

Thomas Klatt
Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany   Fax: +49(89)218077680   Email: [email protected]
,
Tobias D. Blümke
Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany   Fax: +49(89)218077680   Email: [email protected]
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Maximilian A. Ganiek
Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany   Fax: +49(89)218077680   Email: [email protected]
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Paul Knochel*
Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany   Fax: +49(89)218077680   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 10 October 2013

Accepted: 14 October 2013

Publication Date:
13 November 2013 (online)


Abstract

A variety of functionalized 1,2-dizinc reagents can be prepared by an indium-catalyzed insertion of zinc powder into aromatic 1,2-dibromides or 1-bromo-2-triflates. These 1,2-dimetallics undergo Cu- or Pd-catalyzed acylations, allylations, or cross couplings.

Supporting Information

 
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