Synlett 2013; 24(19): 2531-2534
DOI: 10.1055/s-0033-1340058
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© Georg Thieme Verlag Stuttgart · New York

Design and Synthesis of Helically Chiral Spirocyclic P3 Phosphazenes and Characterization of Their Onium Salts

Masahiro Terada*a, b, Kengo Gotoa, Masafumi Oishia, Tadahiro Takedac, Eunsang Kwonb, Azusa Kondoha
  • aDepartment of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan   Fax: +81(22)7956584   Email: mterada@m.tohoku.ac.jp
  • bResearch and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan
  • cProcess Technology Research Laboratories, Daiichi Sankyo Co., Ltd., Edogawa-ku, Tokyo 134-8630, Japan
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Publication History

Received: 03 October 2013

Accepted: 04 October 2013

Publication Date:
28 October 2013 (eFirst)

Abstract

Helically chiral spirocyclic P3 phosphazenes were designed as a novel family of chiral organosuperbases. The newly designed chiral P3 phosphazenes were synthesized from commercially available sources in several steps and characterized by X-ray crystallographic analysis of their onium salts. The optically pure P3 phosphazenium salt was obtained by using preparative chiral stationary phase HPLC and the absolute configuration of the helical chirality was determined.

Supporting Information