Synthesis 2013; 45(24): 3399-3403
DOI: 10.1055/s-0033-1340008
paper
© Georg Thieme Verlag Stuttgart · New York

A Simple Synthesis of the Novel Antihistaminic Drug Olopatadine Hydrochloride­

Subhash P. Chavan*
Division of Organic Chemistry, CSIR-NCL (National Chemical Laboratory), Pune 411008, India   Fax: +91(20)5892629   Email: sp.chavan@ncl.res.in
,
Pradeep B. Lasonkar
Division of Organic Chemistry, CSIR-NCL (National Chemical Laboratory), Pune 411008, India   Fax: +91(20)5892629   Email: sp.chavan@ncl.res.in
› Author Affiliations
Further Information

Publication History

Received: 04 July 2013

Accepted after revision: 18 September 2013

Publication Date:
23 October 2013 (online)


Abstract

A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain.

Supporting Information

 
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